![]() In this study, we describe our early experiences with COVID-19 and clinical characteristics in patients with documented HIV infection. Moreover, some HIV protease inhibitors (PI) are thought to inhibit the 3-chymotrypsin-like protease of coronaviruses. On the other hand, defective cellular immunity in PLWH could paradoxically be protective for severe cytokine dysregulation, which has been observed in patients with COVID-19. Coronaviruses such as severe acute respiratory syndrome (SARS)-CoV and SARS-CoV-2 have been shown to cause transient immune deficiency, indicating that HIV and COVID-19 may both carry deleterious immunological and clinical consequences. A small case series from Spain recently described the clinical characteristics of five PLWH with COVID-19. In the current COVID-19 pandemic, several comorbidities have been identified as risk factors for severe disease and death. ![]() ![]() Consequently, increasing numbers of coronavirus disease (COVID-19) cases are expected to rapidly occur in people living with human immunodeficiency virus (PLWH). On April 27, the number of confirmed worldwide SARS-CoV-2 infections has exceeded up to nearly 3 million cases and nearly 200,000 deaths.
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